MagDot 640 Anti-Human CD19 (HIB19)

The MagDot is a dual-purpose reagent, it combines quantum dots and superparamagnetic iron oxide particles within the same nanoparticle. Cells labeled with MagDots targeting specific antigens will be both fluorescent and magnetic. Therefore, after labeling cells of interest, one can look at the feed to determine the percent positive fluorescently via flow cytometry, and then place the labeled cells in a magnetic separator and analyze both the magnetic (for the enrichment) and the nonmagnetic (for the depletion) of targeted cells without the need for further fluorescent labeling. The HIB19 antibody conjugated to this MagDot reacts with CD19, a 95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells. CD19 can also be found on follicular dendritic cells. CD19 also functions as a co-receptor with CD21 and CD81 for the B cell receptor and is involved in B cell activation and differentiation.